LSM1 blocking peptide

LSM1 Antibody (Center) Blocking Peptide

• Gene Names: LSM1; CASM; YJL124C
• Synonyms: LSM1; LSM1 Antibody (Center) Blocking Peptide; U6 snRNA-associated Sm-like protein LSm1; Cancer-associated Sm-like; Small nuclear ribonuclear CaSm; CASM; LSM1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human LSM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 133

• Cellular Location: Nucleus.
• Tissue Location: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LSM1 blocking peptide

Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA.

NCBI and Uniprot Product Information

• NCBI GI #: 20177943
• NCBI GeneID: 27257
• UniProt Accession #: O15116; B2R5E6
• Molecular Weight: 15,179 Da
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm1
• NCBI Official Synonym Full Names: LSM1 homolog, mRNA degradation associated
• NCBI Official Symbol: LSM1
• NCBI Official Synonym Symbols: CASM; YJL124C
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm1
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm1
• Protein Family: Sm-like protein
• UniProt Gene Name: LSM1
• UniProt Synonym Gene Names: CASM
• UniProt Entry Name: LSM1_HUMAN

NCBI Description

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

Uniprot Description

LSM1: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; RNA cap binding

Biological Process: deadenylation-dependent decapping; RNA splicing; RNA splicing, via transesterification reactions