LAMTOR2 blocking peptide

LAMTOR2 Peptide

Cat. Num. AAA154029

• Gene Names: LAMTOR2; p14; ENDAP; ROBLD3; HSPC003; MAPBPIP; MAPKSP1AP; Ragulator2
• Applications: Blocking (BL)
• Synonyms: LAMTOR2; LAMTOR2 Peptide; p14; ENDAP; ROBLD3; HSPC003; MAPBPIP; MAPKSP1AP; Ragulator2; Ragulator complex protein LAMTOR2; Endosomal adaptor protein p14; MAPBP-interacting protein; late endosomal/lysosomal adaptor; MAPK and MTOR activator 2; LAMTOR2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 125

• Applicable Applications for LAMTOR2 blocking peptide: Blocking (BL)
• Application Notes: The peptide is used for blocking the activity of LAMTOR2 antibody. It usually blocks the antibody activity completely by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acid peptide near the center of human LAMTOR2.
• Preparation and Storage: Store LAMTOR2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 7661728
• NCBI GeneID: 28956
• NCBI Accession #: NP_054736
• NCBI GenBank Nucleotide #: NM_014017.3
• UniProt Accession #: Q9Y2Q5; Q5VY97; Q5VY98; Q5VY99
• Molecular Weight: 10,242 Da
• NCBI Official Full Name: ragulator complex protein LAMTOR2 isoform 1
• NCBI Official Synonym Full Names: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
• NCBI Official Symbol: LAMTOR2
• NCBI Official Synonym Symbols: p14; ENDAP; ROBLD3; HSPC003; MAPBPIP; MAPKSP1AP; Ragulator2
• NCBI Protein Information: ragulator complex protein LAMTOR2; MAPKSP1 adaptor protein; MAPBP-interacting protein; endosomal adaptor protein p14; roadblock domain containing 3; roadblock domain-containing protein 3; late endosomal/lysosomal Mp1-interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; mitogen-activated protein-binding protein-interacting protein (MAPBPIP)
• UniProt Protein Name: Ragulator complex protein LAMTOR2
• Protein Family: Ragulator complex protein
• UniProt Gene Name: LAMTOR2
• UniProt Synonym Gene Names: MAPBPIP; ROBLD3; MAPBP-interacting protein
• UniProt Entry Name: LTOR2_HUMAN

NCBI Description

The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

LAMTOR2: Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: lysosomal membrane; late endosome

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold

Biological Process: activation of MAPKK activity; cell growth; positive regulation of TOR signaling pathway; positive regulation of GTPase activity

Disease: Immunodeficiency Due To Defect In Mapbp-interacting Protein