KCNH7 blocking peptide

KCNH7 Antibody (N-term) Blocking Peptide

• Gene Names: KCNH7; ERG3; HERG3; Kv11.3
• Synonyms: KCNH7; KCNH7 Antibody (N-term) Blocking Peptide; Potassium voltage-gated channel subfamily H member 7; Ether-a-go-go-related gene potassium channel 3; ERG-3; Eag-related protein 3; Ether-a-go-go-related protein 3; hERG-3; Voltage-gated potassium channel subunit Kv113; ERG3; KCNH7 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human KCNH7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1196

• Cellular Location: Membrane; Multi-pass membrane protein.
• Tissue Location: Expressed in prolactin-secreting adenomas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KCNH7 blocking peptide

Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.

NCBI and Uniprot Product Information

• NCBI GI #: 229462892
• NCBI GeneID: 90134
• UniProt Accession #: Q9NS40; Q53QU4; Q53TB7; Q53TP9; Q8IV15
• Molecular Weight: 82,904 Da
• NCBI Official Full Name: Potassium voltage-gated channel subfamily H member 7
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily H member 7
• NCBI Official Symbol: KCNH7
• NCBI Official Synonym Symbols: ERG3; HERG3; Kv11.3
• NCBI Protein Information: potassium voltage-gated channel subfamily H member 7
• UniProt Protein Name: Potassium voltage-gated channel subfamily H member 7
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNH7
• UniProt Synonym Gene Names: ERG3; ERG-3; Eag-related protein 3; Ether-a-go-go-related protein 3; hERG-3
• UniProt Entry Name: KCNH7_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv11.3: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity

Biological Process: regulation of membrane potential