KAT5 / Tip60/HTATIP Blocking Peptide | KAT5 blocking peptide

KAT5 / Tip60/HTATIP Antibody (C-term) Blocking peptide

• Gene Names: KAT5; TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
• Synonyms: KAT5 / Tip60/HTATIP; KAT5 / Tip60/HTATIP Antibody (C-term) Blocking peptide; Histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein; KAT5; HTATIP; TIP60; KAT5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human HTATIP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 513

• Cellular Location: Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note: Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KAT5 blocking peptide

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.

NCBI and Uniprot Product Information

• NCBI GI #: 30923328
• NCBI GeneID: 10524
• UniProt Accession #: Q92993; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q9BWK7; B4E3C7; C9JL99
• Molecular Weight: 56,292 Da
• NCBI Official Full Name: Histone acetyltransferase KAT5
• NCBI Official Synonym Full Names: lysine acetyltransferase 5
• NCBI Official Symbol: KAT5
• NCBI Official Synonym Symbols: TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
• NCBI Protein Information: histone acetyltransferase KAT5
• UniProt Protein Name: Histone acetyltransferase KAT5
• Protein Family: 3-ketoacyl-CoA thiolase
• UniProt Gene Name: KAT5
• UniProt Synonym Gene Names: HTATIP; TIP60; Tip60; HIV-1 Tat interactive protein
• UniProt Entry Name: KAT5_HUMAN

NCBI Description

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: Nucleolus; Nuclear receptor co-regulator; EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus

Molecular Function: acetyltransferase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation; strand displacement