JUP blocking peptide

JUP Antibody (C-term) Blocking Peptide

• Gene Names: JUP; DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12
• Synonyms: JUP; JUP Antibody (C-term) Blocking Peptide; Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3; CTNNG; DP3; JUP blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human JUP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 745

• Cellular Location: Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note: Cytoplasmic in a soluble and membrane-associated form
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for JUP blocking peptide

Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 205371866
• NCBI GeneID: 3728
• UniProt Accession #: P14923; Q15093; Q15151; Q7L3S5; Q86W21; Q9BWC4; Q9HCX9
• Molecular Weight: 81,745 Da
• NCBI Official Full Name: Junction plakoglobin
• NCBI Official Synonym Full Names: junction plakoglobin
• NCBI Official Symbol: JUP
• NCBI Official Synonym Symbols: DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12
• NCBI Protein Information: junction plakoglobin
• UniProt Protein Name: Junction plakoglobin
• Protein Family: Junction plakoglobin
• UniProt Gene Name: JUP
• UniProt Synonym Gene Names: CTNNG; DP3
• UniProt Entry Name: PLAK_HUMAN

NCBI Description

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Description

CTNNG: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: catenin complex; cell-cell adherens junction; cytoplasm; cytoskeleton; cytosol; desmosome; focal adhesion; hemidesmosome; intercellular junction; internal side of plasma membrane; nucleus; plasma membrane; zonula adherens

Molecular Function: alpha-catenin binding; cadherin binding; cell adhesion molecule binding; protein binding; protein homodimerization activity; protein phosphatase binding; structural constituent of cell wall; transcription coactivator activity

Biological Process: cell migration; cell-cell adhesion; detection of mechanical stimulus; positive regulation of protein import into nucleus; positive regulation of transcription factor activity; regulation of cell proliferation

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease