JMJD6 (PTDSR) Blocking Peptide | Jmjd6 blocking peptide

JMJD6 (PTDSR) Blocking Peptide (N-term)

• Gene Names: Jmjd6; Ptdsr
• Synonyms: JMJD6 (PTDSR); JMJD6 (PTDSR) Blocking Peptide (N-term); Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 11411-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; Jmjd6; Ptdsr; Jmjd6 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 1-18 of RAT Jmjd6
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 403

• Cellular Location: Nucleus, nucleoplasm. Nucleus, nucleolus. Note: Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle (By similarity).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Jmjd6 blocking peptide

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 67460663
• NCBI GeneID: 360665
• UniProt Accession #: Q6AYK2; Q9ERI5; Q6NYC1; Q5ZMK5; Q58DS6
• Molecular Weight: 46,540 Da
• NCBI Official Full Name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• NCBI Official Synonym Full Names: jumonji domain containing 6
• NCBI Official Symbol: Jmjd6
• NCBI Official Synonym Symbols: Ptdsr
• NCBI Protein Information: bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• UniProt Protein Name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• Protein Family: Bifunctional arginine demethylase and lysyl-hydroxylase
• UniProt Gene Name: Jmjd6
• UniProt Synonym Gene Names: Ptdsr; Protein PTDSR
• UniProt Entry Name: JMJD6_RAT

Uniprot Description

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses ().