ITPK1 blocking peptide

ITPK1 Antibody (N-term) Blocking Peptide

• Gene Names: ITPK1; ITRPK1
• Synonyms: ITPK1; ITPK1 Antibody (N-term) Blocking Peptide; Inositol-tetrakisphosphate 1-kinase; Inositol 1;4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1;4)P(3) 5/6-kinase; ITPK1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 414

• Tissue Location: Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ITPK1 blocking peptide

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

NCBI and Uniprot Product Information

• NCBI GI #: 83288249
• NCBI GeneID: 3705
• UniProt Accession #: Q13572; Q9BTL6; Q9H2E7
• Molecular Weight: 35,632 Da
• NCBI Official Full Name: Inositol-tetrakisphosphate 1-kinase
• NCBI Official Synonym Full Names: inositol-tetrakisphosphate 1-kinase
• NCBI Official Symbol: ITPK1
• NCBI Official Synonym Symbols: ITRPK1
• NCBI Protein Information: inositol-tetrakisphosphate 1-kinase
• UniProt Protein Name: Inositol-tetrakisphosphate 1-kinase
• Protein Family: Inositol-tetrakisphosphate 1-kinase
• UniProt Gene Name: ITPK1
• UniProt Synonym Gene Names: Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase
• UniProt Entry Name: ITPK1_HUMAN

NCBI Description

This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]

Uniprot Description

ITPK1: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Belongs to the ITPK1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.134; EC 2.7.1.159

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: cytosol

Molecular Function: catalytic activity; inositol tetrakisphosphate 1-kinase activity

Biological Process: blood coagulation; inositol phosphate metabolic process; signal transduction