ING1 blocking peptide

ING1 Antibody (N-term) Blocking Peptide

• Gene Names: ING1; p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
• Synonyms: ING1; ING1 Antibody (N-term) Blocking Peptide; Inhibitor of growth protein 1; ING1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 422

• Cellular Location: Nucleus.
• Tissue Location: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ING1 blocking peptide

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

NCBI and Uniprot Product Information

• NCBI GI #: 212276438
• NCBI GeneID: 3621
• UniProt Accession #: Q9UK53; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83
• Molecular Weight: 29,572 Da
• NCBI Official Full Name: Inhibitor of growth protein 1
• NCBI Official Synonym Full Names: inhibitor of growth family member 1
• NCBI Official Symbol: ING1
• NCBI Official Synonym Symbols: p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
• NCBI Protein Information: inhibitor of growth protein 1
• UniProt Protein Name: Inhibitor of growth protein 1
• Protein Family: Inhibitor of growth protein
• UniProt Gene Name: ING1
• UniProt Entry Name: ING1_HUMAN

NCBI Description

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

ING1: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: methylated histone residue binding; protein binding

Disease: Squamous Cell Carcinoma, Head And Neck