IL17RE blocking peptide

IL17RE Blocking Peptide(N-term)

• Synonyms: IL17RE; IL17RE Blocking Peptide(N-term); Interleukin-17 receptor E; IL-17 receptor E; IL-17RE; IL17RE blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 102-116 of HUMAN IL17RE
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 533

• Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Secreted.
• Tissue Location: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IL17RE blocking peptide

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

NCBI and Uniprot Product Information

• NCBI GI #: 301129210
• NCBI GeneID: 132014
• NCBI Accession #: NP_001180309.1
• NCBI GenBank Nucleotide #: NM_001193380.1
• UniProt Accession #: Q8NFR9; Q6P532; Q8N8H7; Q8N8H8; Q8TEC2; B2RB34; B2RNR1; B9EH65
• Molecular Weight: 30,781 Da
• NCBI Official Full Name: interleukin-17 receptor E isoform 6
• NCBI Official Synonym Full Names: interleukin 17 receptor E
• NCBI Official Symbol: IL17RE
• NCBI Protein Information: interleukin-17 receptor E
• UniProt Protein Name: Interleukin-17 receptor E
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RE
• UniProt Synonym Gene Names: IL-17 receptor E; IL-17RE
• UniProt Entry Name: I17RE_HUMAN

NCBI Description

This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

IL17RE: Receptor which can activate the MAPK signaling pathway and seems to function at or upstream of Ras. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interleukin-17 receptor activity; protein binding