IGF2R blocking peptide

IGF2R Blocking Peptide (C-Term)

• Gene Names: IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R
• Synonyms: IGF2R; IGF2R Blocking Peptide (C-Term); Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222; MPRI; IGF2R blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 2444-2458 of HUMAN IGF2R
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 2491

• Cellular Location: Lysosome membrane; Single-pass type I membrane protein. Note: Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IGF2R blocking peptide

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

NCBI and Uniprot Product Information

• NCBI GI #: 317373416
• NCBI GeneID: 3482
• UniProt Accession #: P11717; Q7Z7G9; Q96PT5
• Molecular Weight: 274,375 Da
• NCBI Official Full Name: Cation-independent mannose-6-phosphate receptor
• NCBI Official Synonym Full Names: insulin like growth factor 2 receptor
• NCBI Official Symbol: IGF2R
• NCBI Official Synonym Symbols: MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R
• NCBI Protein Information: cation-independent mannose-6-phosphate receptor
• UniProt Protein Name: Cation-independent mannose-6-phosphate receptor
• Protein Family: Cation-independent mannose-6-phosphate receptor
• UniProt Gene Name: IGF2R
• UniProt Synonym Gene Names: MPRI; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R
• UniProt Entry Name: MPRI_HUMAN

NCBI Description

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]

Uniprot Description

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.

Protein type: Membrane protein, integral; Receptor, misc.; Vesicle

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cell surface; early endosome; endocytic vesicle; endosome; focal adhesion; integral to plasma membrane; late endosome; membrane; trans-Golgi network; trans-Golgi network membrane; trans-Golgi network transport vesicle; transport vesicle

Molecular Function: glycoprotein binding; identical protein binding; insulin-like growth factor receptor activity; phosphoprotein binding; protein binding; receptor activity

Biological Process: receptor-mediated endocytosis; signal transduction

Disease: Hepatocellular Carcinoma