HOP2 blocking peptide

HOP2 Blocking Peptide

Cat. Num. AAA9621770

• Gene Names: PSMC3IP; HOP2; ODG3; GT198; TBPIP; HUMGT198A
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: HOP2; HOP2 Blocking Peptide; DBD interacting; GT198; Homologous pairing protein 2 homolog; Homologous-pairing protein 2 homolog; HOP2_HUMAN; Nuclear receptor coactivator GT198; Proteasome 26S ATPase subunit 3 interacting protein; Proteasome 26S ATPase subunit 3-interacting protein; PSMC3 interacting protein; PSMC3-interacting protein; Psmc3ip; Tat binding protein 1-interacting protein; Tat-binding protein 1-interacting protein; TBP-1-interacting protein; TBP1 interacting protein; TBPIP; HOP2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for HOP2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HOP2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 7706577
• NCBI GeneID: 29893
• NCBI Accession #: NP_057640
• NCBI GenBank Nucleotide #: NP_057640.1
• UniProt Accession #: Q9P2W1; Q14458; Q8WXG2; Q96HA2; C5ILB7
• Molecular Weight: 11,070 Da
• NCBI Official Full Name: homologous-pairing protein 2 homolog isoform 2
• NCBI Official Synonym Full Names: PSMC3 interacting protein
• NCBI Official Symbol: PSMC3IP
• NCBI Official Synonym Symbols: HOP2; ODG3; GT198; TBPIP; HUMGT198A
• NCBI Protein Information: homologous-pairing protein 2 homolog
• UniProt Protein Name: Homologous-pairing protein 2 homolog
• Protein Family: Homologous-pairing protein
• UniProt Gene Name: PSMC3IP
• UniProt Synonym Gene Names: HOP2; TBPIP; TBP-1-interacting protein
• UniProt Entry Name: HOP2_HUMAN

NCBI Description

This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Uniprot Description

PSMC3IP: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Defects in PSMC3IP are the cause of ovarian dysgenesis type 3 (ODG3). A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Belongs to the HOP2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: nucleus

Molecular Function: DNA binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: meiotic cell cycle; DNA recombination

Disease: Ovarian Dysgenesis 3