HOOK2 blocking peptide

HOOK2 Blocking Peptide (N-term)

• Gene Names: HOOK2; HK2
• Synonyms: HOOK2; HOOK2 Blocking Peptide (N-term); Protein Hook homolog 2; h-hook2; hHK2; HOOK2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 162-177 of HUMAN HOOK2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 719

• Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton Note: Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HOOK2 blocking peptide

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

NCBI and Uniprot Product Information

• NCBI GI #: 296439323
• NCBI GeneID: 29911
• UniProt Accession #: Q96ED9; O60562
• Molecular Weight: 83,022 Da
• NCBI Official Full Name: Protein Hook homolog 2
• NCBI Official Synonym Full Names: hook microtubule tethering protein 2
• NCBI Official Symbol: HOOK2
• NCBI Official Synonym Symbols: HK2
• NCBI Protein Information: protein Hook homolog 2
• UniProt Protein Name: Protein Hook homolog 2
• Protein Family: Protein Hook
• UniProt Gene Name: HOOK2
• UniProt Synonym Gene Names: h-hook2; hHK2
• UniProt Entry Name: HOOK2_HUMAN

NCBI Description

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Uniprot Description

HOOK2: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Belongs to the hook family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: centrosome

Molecular Function: identical protein binding; protein binding

Biological Process: early endosome to late endosome transport; endocytosis; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis