HCLS1 blocking peptide

HCLS1 Antibody (C-term) Blocking peptide

• Gene Names: HCLS1; HS1; p75; CTTNL; lckBP1
• Synonyms: HCLS1; HCLS1 Antibody (C-term) Blocking peptide; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75; HS1; HCLS1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of HCLS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 486

• Cellular Location: Membrane; Peripheral membrane protein Cytoplasm. Mitochondrion
• Tissue Location: Expressed only in tissues and cells of hematopoietic origin
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HCLS1 blocking peptide

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

NCBI and Uniprot Product Information

• NCBI GI #: 317373440
• NCBI GeneID: 3059
• UniProt Accession #: P14317; Q53Y93; Q6IBK9; Q9UDK0; B4DQ69
• Molecular Weight: 24,008 Da
• NCBI Official Full Name: Hematopoietic lineage cell-specific protein
• NCBI Official Synonym Full Names: hematopoietic cell-specific Lyn substrate 1
• NCBI Official Symbol: HCLS1
• NCBI Official Synonym Symbols: HS1; p75; CTTNL; lckBP1
• NCBI Protein Information: hematopoietic lineage cell-specific protein
• UniProt Protein Name: Hematopoietic lineage cell-specific protein
• Protein Family: HCLS1-binding protein
• UniProt Gene Name: HCLS1
• UniProt Synonym Gene Names: HS1
• UniProt Entry Name: HCLS1_HUMAN

Uniprot Description

HS1: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS. Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54. Expressed only in tissues and cells of hematopoietic origin.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: cytoplasm; nucleus; transcription factor complex

Molecular Function: protein binding; protein kinase binding

Biological Process: erythrocyte differentiation; positive regulation of cell proliferation; positive regulation of granulocyte differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; regulation of actin filament polymerization; regulation of transcription, DNA-dependent; response to hormone stimulus