GRSF1 blocking peptide

GRSF1 Antibody (Center) Blocking Peptide

• Synonyms: GRSF1; GRSF1 Antibody (Center) Blocking Peptide; G-rich sequence factor 1; GRSF-1; GRSF1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 480

• Cellular Location: Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note: Forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GRSF1 blocking peptide

Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.

NCBI and Uniprot Product Information

• NCBI GI #: 215274142
• NCBI GeneID: 2926
• UniProt Accession #: Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2; B3KPW0
• Molecular Weight: 36,613 Da
• NCBI Official Full Name: G-rich sequence factor 1
• NCBI Official Synonym Full Names: G-rich RNA sequence binding factor 1
• NCBI Official Symbol: GRSF1
• NCBI Protein Information: G-rich sequence factor 1
• UniProt Protein Name: G-rich sequence factor 1
• Protein Family: G-rich sequence factor
• UniProt Gene Name: GRSF1
• UniProt Synonym Gene Names: GRSF-1
• UniProt Entry Name: GRSF1_HUMAN

NCBI Description

The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GRSF1: Binds RNAs containing the 14 base G-rich element. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: cytoplasm; mitochondrion

Molecular Function: mRNA binding; RNA binding

Biological Process: mRNA polyadenylation