GRK7 blocking peptide

GRK7 Antibody (C-term) Blocking Peptide

• Gene Names: GRK7; GPRK7
• Synonyms: GRK7; GRK7 Antibody (C-term) Blocking Peptide; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7; GPRK7; GRK7 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human GRK7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 553

• Cellular Location: Membrane; Lipid-anchor
• Tissue Location: Retinal cones, outer and inner segments.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GRK7 blocking peptide

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

NCBI and Uniprot Product Information

• NCBI GI #: 21263659
• NCBI GeneID: 131890
• UniProt Accession #: Q8WTQ7
• Molecular Weight: 62,212 Da
• NCBI Official Full Name: Rhodopsin kinase
• NCBI Official Synonym Full Names: G protein-coupled receptor kinase 7
• NCBI Official Symbol: GRK7
• NCBI Official Synonym Symbols: GPRK7
• NCBI Protein Information: rhodopsin kinase
• UniProt Protein Name: Rhodopsin kinase
• Protein Family: Rhodopsin kinase
• UniProt Gene Name: GRK7
• UniProt Synonym Gene Names: GPRK7
• UniProt Entry Name: GRK7_HUMAN

NCBI Description

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]

Uniprot Description

GRK7: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Protein type: EC 2.7.11.14; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.16; AGC group; GRK family; GRK subfamily

Chromosomal Location of Human Ortholog: 3q24

Molecular Function: rhodopsin kinase activity

Biological Process: protein amino acid autophosphorylation; regulation of rhodopsin mediated signaling