GRK1 blocking peptide

GRK1 Antibody (C-term) Blocking Peptide

• Gene Names: GRK1; RK; RHOK; GPRK1
• Synonyms: GRK1; GRK1 Antibody (C-term) Blocking Peptide; Rhodopsin kinase; RK; G protein-coupled receptor kinase 1; RHOK; GRK1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human GRK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 563

• Cellular Location: Membrane; Lipid-anchor
• Tissue Location: Retinal-specific. Expressed in rods and cones cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GRK1 blocking peptide

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.

NCBI and Uniprot Product Information

• NCBI GI #: 2833269
• NCBI GeneID: 6011
• UniProt Accession #: Q15835; Q53X14
• Molecular Weight: 63,526 Da
• NCBI Official Full Name: Rhodopsin kinase
• NCBI Official Synonym Full Names: G protein-coupled receptor kinase 1
• NCBI Official Symbol: GRK1
• NCBI Official Synonym Symbols: RK; RHOK; GPRK1
• NCBI Protein Information: rhodopsin kinase
• UniProt Protein Name: Rhodopsin kinase
• UniProt Gene Name: GRK1
• UniProt Synonym Gene Names: RHOK; RK
• UniProt Entry Name: RK_HUMAN

NCBI Description

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

Uniprot Description

GRK1: a Ser/Thr of the GRK family. Phosphorylates and inactivates photon-activated rhodopsin. LOF mutations lead to type 2 Oguchi disease, a form of night blindness. A link between RHOK and retinitis pigmentosa is now thought to be unlikely

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.14; AGC group; GRK family; GRK subfamily

Chromosomal Location of Human Ortholog: 13q34

Molecular Function: protein kinase activity; rhodopsin kinase activity

Biological Process: protein amino acid autophosphorylation; regulation of G-protein coupled receptor protein signaling pathway; regulation of rhodopsin mediated signaling; rhodopsin mediated signaling

Disease: Oguchi Disease 2