GRIK5 blocking peptide

Grik5 Peptide

Cat. Num. AAA152294

• Gene Names: GRIK5; KA2; EAA2; GRIK2; GluK5
• Applications: Blocking (BL)
• Synonyms: Grik5; Grik5 Peptide; KA2; EAA2; GRIK2; GluK5; Glutamate receptor ionotropic; kainate 5; Excitatory amino acid receptor 2; glutamate receptor; ionotropic; GRIK5 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 980

• Applicable Applications for GRIK5 blocking peptide: Blocking (BL)
• Application Notes: Grik5 peptide is used for blocking the activity of Grik5 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acids near the carboxy terminus of human Grik5.
• Preparation and Storage: Store Grik5 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 29029597
• NCBI GeneID: 2901
• NCBI Accession #: NP_002079
• NCBI GenBank Nucleotide #: NM_002088.4
• UniProt Accession #: Q16478; Q8WWG8
• Molecular Weight: 109,658 Da
• NCBI Official Full Name: glutamate receptor ionotropic, kainate 5 isoform 2
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, kainate 5
• NCBI Official Symbol: GRIK5
• NCBI Official Synonym Symbols: KA2; EAA2; GRIK2; GluK5
• NCBI Protein Information: glutamate receptor ionotropic, kainate 5; glutamate receptor KA2; excitatory amino acid receptor 2
• UniProt Protein Name: Glutamate receptor ionotropic, kainate 5
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIK5
• UniProt Synonym Gene Names: GRIK2; GluK5; EAA2; KA2
• UniProt Entry Name: GRIK5_HUMAN

NCBI Description

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: identical protein binding; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; SH3 domain binding; PDZ domain binding

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; positive regulation of neuron apoptosis; regulation of synaptic vesicle fusion to presynaptic membrane; regulation of excitatory postsynaptic membrane potential; receptor clustering; protein retention in ER; establishment of cellular localization