GPR3 blocking peptide

GPR3 Peptide

Cat. Num. AAA151887

• Gene Names: GPR3; ACCA
• Applications: Blocking (BL)
• Synonyms: GPR3; GPR3 Peptide; ACCA; G-protein coupled receptor 3; ACCA orphan receptor; G protein-coupled receptor 3; GPR3 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 330

• Applicable Applications for GPR3 blocking peptide: Blocking (BL)
• Application Notes: GPR3 peptide is used for blocking the activity of GPR3 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 13 amino acids near the carboxy terminus of human GPR3.
• Preparation and Storage: Store GPR3 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 1170006
• NCBI GeneID: 2827
• UniProt Accession #: P46089; A8K570
• Molecular Weight: 35,010 Da
• NCBI Official Full Name: G-protein coupled receptor 3
• NCBI Official Synonym Full Names: G protein-coupled receptor 3
• NCBI Official Symbol: GPR3
• NCBI Official Synonym Symbols: ACCA
• NCBI Protein Information: G-protein coupled receptor 3; ACCA orphan receptor; adenylate cyclase constitutive activator
• UniProt Protein Name: G-protein coupled receptor 3
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR3
• UniProt Synonym Gene Names: ACCA
• UniProt Entry Name: GPR3_HUMAN

NCBI Description

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

Uniprot Description

GPR3: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons and neurite outgrowth. Maintains also meiotic arrest in oocytes. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Cell cycle regulation; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36.1-p35

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; regulation of meiosis; positive regulation of cAMP metabolic process; G-protein signaling, adenylate cyclase activating pathway