GNG5 blocking peptide

GNG5 Blocking Peptide (C-Term)

• Synonyms: GNG5; GNG5 Blocking Peptide (C-Term); Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; GNGT5; GNG5 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 54-63 of HUMAN GNG5
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 68

• Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GNG5 blocking peptide

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

NCBI and Uniprot Product Information

• NCBI GI #: 52783599
• NCBI GeneID: 2787
• UniProt Accession #: P63218; P30670; Q5VX54; Q61015; B2R5A0
• Molecular Weight: 7,318 Da
• NCBI Official Full Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
• NCBI Official Synonym Full Names: G protein subunit gamma 5
• NCBI Official Symbol: GNG5
• NCBI Protein Information: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
• UniProt Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
• UniProt Gene Name: GNG5
• UniProt Synonym Gene Names: GNGT5
• UniProt Entry Name: GBG5_HUMAN

NCBI Description

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

Uniprot Description

G-gamma 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the G protein gamma family.

Protein type: G protein, heterotrimeric; G protein, heterotrimeric gamma; G protein; Mitochondrial

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: membrane; plasma membrane

Molecular Function: PDZ domain binding; protein binding