GLMN blocking peptide
GLMN Antibody (C-term) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Description
GLMN: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Defects in GLMN are the cause of glomuvenous malformations (GVMs). GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex
Molecular Function: hepatocyte growth factor receptor binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase inhibitor activity
Biological Process: muscle cell differentiation; negative regulation of T cell proliferation; positive regulation of cytokine secretion; positive regulation of interleukin-2 biosynthetic process; positive regulation of phosphorylation; regulation of gene expression, epigenetic; regulation of proteasomal ubiquitin-dependent protein catabolic process; vasculogenesis
Disease: Glomuvenous Malformations
Research Articles on GLMN
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Product Notes
The GLMN glmn (Catalog #AAA9218823) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GLMN, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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