GIT2 blocking peptide

GIT2 (D391) Peptide

Cat. Num. AAA3002122

• Gene Names: GIT2; PKL; CAT2; CAT-2
• Applications: Blocking
• Purity: Synthetic peptide GIT2 (D391). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: GIT2; GIT2 (D391) Peptide; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; KIAA0148; GIT2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002121 GIT2 (D391) pAb.
• Purity/Purification: Synthetic peptide GIT2 (D391). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 681

• Applicable Applications for GIT2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for GIT2 blocking peptide

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases(GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of beta2-adrenergic receptor, thus reducing beta2-adrenergic receptor signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 206725420
• NCBI GeneID: 9815
• NCBI Accession #: NP_001128685.1
• NCBI GenBank Nucleotide #: NP_001128685.1
• UniProt Accession #: Q14161
• NCBI Official Full Name: ARF GTPase-activating protein GIT2 isoform 6
• NCBI Official Synonym Full Names: GIT ArfGAP 2
• NCBI Official Symbol: GIT2
• NCBI Official Synonym Symbols: PKL; CAT2; CAT-2
• NCBI Protein Information: ARF GTPase-activating protein GIT2
• UniProt Protein Name: ARF GTPase-activating protein GIT2
• Protein Family: ARF GTPase-activating protein
• UniProt Gene Name: GIT2
• UniProt Synonym Gene Names: KIAA0148; ARF GAP GIT2; CAT-2; CAT2
• UniProt Entry Name: GIT2_HUMAN

NCBI Description

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

Uniprot Description

GIT2: possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats.

Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPs

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: nucleoplasm; focal adhesion

Molecular Function: protein binding; zinc ion binding

Biological Process: behavioral response to pain; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity