GBP1 blocking peptide

GBP1 Antibody (N-term) Blocking peptide

• Synonyms: GBP1; GBP1 Antibody (N-term) Blocking peptide; Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; GBP1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 592

• Cellular Location: Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Note: Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GBP1 blocking peptide

Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

NCBI and Uniprot Product Information

• NCBI GI #: 311033383
• NCBI GeneID: 2633
• UniProt Accession #: P32455; Q5T8M1; D3DT26
• Molecular Weight: 67,931 Da
• NCBI Official Full Name: Guanylate-binding protein 1
• NCBI Official Synonym Full Names: guanylate binding protein 1
• NCBI Official Symbol: GBP1
• NCBI Protein Information: guanylate-binding protein 1
• UniProt Protein Name: Guanylate-binding protein 1
• Protein Family: Guanylate-binding protein
• UniProt Gene Name: GBP1
• UniProt Synonym Gene Names: GBP-1; HuGBP-1
• UniProt Entry Name: GBP1_HUMAN

NCBI Description

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

Uniprot Description

GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.

Protein type: Vesicle; Cell adhesion; Hydrolase

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: cytosol

Molecular Function: actin binding; cytokine binding; enzyme binding; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding

Biological Process: negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling