Gads blocking peptide

Gads (N158) Peptide

Cat. Num. AAA3004401

• Gene Names: GRAP2; P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
• Applications: Blocking
• Purity: Synthetic peptide Gads (N158). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Gads; Gads (N158) Peptide; DCE 2; DCE2; GAD 2; GAD 65; GAD-2; GAD-65; GAD2; Glutamate Decarboxylase 2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2 (pancreat; Gads blocking peptide

• Specificity: This peptide can be used with studies using MBS3004400 Gads (N158) pAb.
• Purity/Purification: Synthetic peptide Gads (N158). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 330

• Applicable Applications for Gads blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Gads blocking peptide

In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-gamma, within structural proteins, such as spectrin or myosin, and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids that bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. Deletion or mutation of SH3 domains generally activates the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. Gads is an adapter proteins that contains both SH2 and SH3 domains. Gads binds to tyrosine-phosphorylated proteins, such as Shc, and functions to couple these proteins to downstream effectors.

NCBI and Uniprot Product Information

• NCBI GI #: 4758476
• NCBI GeneID: 9402
• NCBI Accession #: NP_004801.1
• NCBI GenBank Nucleotide #: NP_004801.1
• UniProt Accession #: O75791
• NCBI Official Full Name: GRB2-related adapter protein 2 isoform 1
• NCBI Official Synonym Full Names: GRB2 related adaptor protein 2
• NCBI Official Symbol: GRAP2
• NCBI Official Synonym Symbols: P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
• NCBI Protein Information: GRB2-related adapter protein 2
• UniProt Protein Name: GRB2-related adapter protein 2
• UniProt Gene Name: GRAP2
• UniProt Synonym Gene Names: GADS; GRB2L; GRID; GRB2L; Grf-40
• UniProt Entry Name: GRAP2_HUMAN

NCBI Description

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Description

GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of signal transduction; cell-cell signaling; Ras protein signal transduction; T cell costimulation; innate immune response; T cell receptor signaling pathway