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FRG1 blocking peptide

FRG1 Antibody (C-term) Blocking Peptide

Gene Names
FRG1; FSG1; FRG1A
Synonyms
FRG1; FRG1 Antibody (C-term) Blocking Peptide; Protein FRG1; FSHD region gene 1 protein; FRG1 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
258
Cellular Location
Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line Note: Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post- differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation
Tissue Location
Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for FRG1 blocking peptide
Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase SUV420H1.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
29,172 Da
NCBI Official Full Name
Protein FRG1
NCBI Official Synonym Full Names
FSHD region gene 1
NCBI Official Symbol
FRG1
NCBI Official Synonym Symbols
FSG1; FRG1A
NCBI Protein Information
protein FRG1
UniProt Protein Name
Protein FRG1
Protein Family
UniProt Gene Name
FRG1
UniProt Entry Name
FRG1_HUMAN

NCBI Description

This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus. [provided by RefSeq, Jul 2008]

Uniprot Description

FRG1: May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be involved in pre- mRNA splicing. Belongs to the FRG1 family.

Protein type: RNA splicing; Nucleolus; Spliceosome

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: nucleolus

Molecular Function: actin filament binding; protein binding

Biological Process: nuclear mRNA splicing, via spliceosome

Disease: Facioscapulohumeral Muscular Dystrophy 1

Research Articles on FRG1

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Product Notes

The FRG1 frg1 (Catalog #AAA9221902) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FRG1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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