FIS1 blocking peptide

FIS1 Blocking Peptide (N-term)

Gene Names

FIS1; TTC11; CGI-135

Synonyms

FIS1; FIS1 Blocking Peptide (N-term); Mitochondrial fission 1 protein; FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11; FIS1 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 6-20 of HUMAN FIS1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

152

Cellular Location

Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FIS1 blocking peptide

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

NCBI and Uniprot Product Information

NCBI GI #

33112470

NCBI GeneID

51024

UniProt Accession #

Q9Y3D6; Q9BTP3

Molecular Weight

16,938 Da

NCBI Official Full Name

Mitochondrial fission 1 protein

NCBI Official Synonym Full Names

fission, mitochondrial 1

NCBI Official Symbol

FIS1

NCBI Official Synonym Symbols

TTC11; CGI-135

NCBI Protein Information

mitochondrial fission 1 protein

UniProt Protein Name

Mitochondrial fission 1 protein

Protein Family

Mitochondria fission 1 protein

UniProt Gene Name

FIS1

UniProt Synonym Gene Names

TTC11; hFis1; TPR repeat protein 11

UniProt Entry Name

FIS1_HUMAN

NCBI Description

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

Uniprot Description

FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family.

Protein type: Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex

Molecular Function: protein binding; receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria

Research Articles on FIS1

1. Results show that Fis1 is significantly overexpressed in malignant oncocytomas.

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Product Notes

The FIS1 fis1 (Catalog #AAA9229312) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FIS1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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FIS1 blocking peptide