Fgr blocking peptide

Mouse Fgr Blocking Peptide (Center)

• Synonyms: Fgr; Mouse Fgr Blocking Peptide (Center); Tyrosine-protein kinase Fgr; Proto-oncogene c-Fgr; p55-Fgr; Fgr blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 232-245 of HUMAN Fgr
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 517

• Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space Note: Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Fgr blocking peptide

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673 and PubMed:9687507). Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

NCBI and Uniprot Product Information

• NCBI GI #: 341940698
• NCBI GeneID: 14191
• UniProt Accession #: P14234; Q61404; Q8BGM0
• Molecular Weight: 58,867 Da
• NCBI Official Full Name: Tyrosine-protein kinase Fgr
• NCBI Official Synonym Full Names: FGR proto-oncogene, Src family tyrosine kinase
• NCBI Official Symbol: Fgr
• NCBI Protein Information: tyrosine-protein kinase Fgr
• UniProt Protein Name: Tyrosine-protein kinase Fgr
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: Fgr
• UniProt Entry Name: FGR_MOUSE

Uniprot Description

FGR: a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers.

Protein type: Oncoprotein; Kinase, protein; Protein kinase, TK; Mitochondrial; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; TK group; Src family

Cellular Component: actin cytoskeleton; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase binding; protein-tyrosine kinase activity

Biological Process: cell differentiation; defense response to Gram-positive bacterium; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell proliferation; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway