FADD (S191) Blocking Peptide | Fadd blocking peptide

Phospho-mouse FADD(S191) Antibody Blocking peptide

• Gene Names: Fadd; Mort1/FADD
• Synonyms: FADD (S191); Phospho-mouse FADD(S191) Antibody Blocking peptide; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Protein FADD; Fadd; Mort1; Fadd blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the region of human Mouse Phospho-FADD-S191. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 205

• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Fadd blocking peptide

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 2498356
• NCBI GeneID: 14082
• UniProt Accession #: Q61160; Q3TC37; Q61082
• Molecular Weight: 22,960 Da
• NCBI Official Full Name: FAS-associated death domain protein
• NCBI Official Synonym Full Names: Fas (TNFRSF6)-associated via death domain
• NCBI Official Symbol: Fadd
• NCBI Official Synonym Symbols: Mort1/FADD
• NCBI Protein Information: FAS-associated death domain protein
• UniProt Protein Name: FAS-associated death domain protein
• Protein Family: Fas-associated death domain protein
• UniProt Gene Name: Fadd
• UniProt Synonym Gene Names: Mort1
• UniProt Entry Name: FADD_MOUSE

Uniprot Description

FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Protein type: Adaptor/scaffold; Apoptosis

Cellular Component: CD95 death-inducing signaling complex; cytoplasm; cytosol; lipid raft; neuron projection; plasma membrane; protein complex

Molecular Function: death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; cardiac muscle development; defense response to virus; innate immune response; lymph node development; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; protein heterooligomerization; spleen development; T cell differentiation; T cell differentiation in the thymus; T cell homeostasis; thymus development