EXTL2 blocking peptide

EXTL2 Antibody (C-term) Blocking Peptide

• Gene Names: EXTL2; EXTR2
• Synonyms: EXTL2; EXTL2 Antibody (C-term) Blocking Peptide; Exostosin-like 2; Alpha-1;4-N-acetylhexosaminyltransferase EXTL2; Alpha-GalNAcT EXTL2; EXT-related protein 2; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Processed exostosin-like 2; EXTR2; EXTL2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human EXTL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 330

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
• Tissue Location: Ubiquitous.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EXTL2 blocking peptide

Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

NCBI and Uniprot Product Information

• NCBI GI #: 9296986
• NCBI GeneID: 2135
• UniProt Accession #: Q9UBQ6; B2R795; D3DT60
• Molecular Weight: 37,466 Da
• NCBI Official Full Name: Exostosin-like 2
• NCBI Official Synonym Full Names: exostosin like glycosyltransferase 2
• NCBI Official Symbol: EXTL2
• NCBI Official Synonym Symbols: EXTR2
• NCBI Protein Information: exostosin-like 2
• UniProt Protein Name: Exostosin-like 2
• Protein Family: Exostosin
• UniProt Gene Name: EXTL2
• UniProt Synonym Gene Names: EXTR2
• UniProt Entry Name: EXTL2_HUMAN

Uniprot Description

EXTL2: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Belongs to the glycosyltransferase 47 family.

Protein type: Transferase; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.223; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: endoplasmic reticulum

Molecular Function: alpha-1,4-N-acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Biological Process: N-acetylglucosamine metabolic process; UDP-N-acetylgalactosamine metabolic process