EVI5 blocking peptide

EVI5 Antibody (Center) Blocking peptide

• Gene Names: EVI5; NB4S; EVI-5
• Synonyms: EVI5; EVI5 Antibody (Center) Blocking peptide; Ecotropic viral integration site 5 protein homolog; EVI-5; Neuroblastoma stage 4S gene protein; NB4S; EVI5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human EVI5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 810

• Cellular Location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note: Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis
• Tissue Location: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EVI5 blocking peptide

Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.

NCBI and Uniprot Product Information

• NCBI GI #: 313104239
• NCBI GeneID: 7813
• UniProt Accession #: O60447; Q9H1Y9; A6NKX8; B9A6J0
• Molecular Weight: 94,133 Da
• NCBI Official Full Name: Ecotropic viral integration site 5 protein homolog
• NCBI Official Synonym Full Names: ecotropic viral integration site 5
• NCBI Official Symbol: EVI5
• NCBI Official Synonym Symbols: NB4S; EVI-5
• NCBI Protein Information: ecotropic viral integration site 5 protein homolog
• UniProt Protein Name: Ecotropic viral integration site 5 protein homolog
• Protein Family: EVI5-like protein
• UniProt Gene Name: EVI5
• UniProt Synonym Gene Names: NB4S; EVI-5
• UniProt Entry Name: EVI5_HUMAN

Uniprot Description

EVI5: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.

Chromosomal Location of Human Ortholog: 1p22.1

Cellular Component: cytosol; endomembrane system; Golgi apparatus; intracellular membrane-bound organelle

Molecular Function: GTPase activator activity; protein binding; Rab GTPase binding

Biological Process: cell proliferation; intracellular protein transport; multicellular organismal development; regulation of vesicle fusion; retrograde transport, endosome to Golgi