eRF3a blocking peptide

eRF3a (D128) Peptide

Cat. Num. AAA3013609

• Gene Names: GSPT1; GST1; ETF3A; eRF3a; 551G9.2
• Applications: Blocking
• Purity: Synthetic peptide eRF3a (D128). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: eRF3a; eRF3a (D128) Peptide; eRF 3a; GSPT 1; GSPT1; GST 1; GST1; GTP binding protein GST1 HS; Transition protein 1; eRF3a blocking peptide

• Specificity: This peptide can be used with studies using MBS3013598 eRF3a (D128) pAb.
• Purity/Purification: Synthetic peptide eRF3a (D128). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 636

• Applicable Applications for eRF3a blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for eRF3a blocking peptide

eRF3a (eukaryotic peptide chain release factor subunit 3a), also known as GSPT1 (G1 to S phase transition 1), is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.

NCBI and Uniprot Product Information

• NCBI GI #: 194097354
• NCBI GeneID: 2935
• NCBI Accession #: NP_001123478.1
• NCBI GenBank Nucleotide #: NP_001123478.1
• UniProt Accession #: P15170
• NCBI Official Full Name: eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2
• NCBI Official Synonym Full Names: G1 to S phase transition 1
• NCBI Official Symbol: GSPT1
• NCBI Official Synonym Symbols: GST1; ETF3A; eRF3a; 551G9.2
• NCBI Protein Information: eukaryotic peptide chain release factor GTP-binding subunit ERF3A
• UniProt Protein Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
• UniProt Gene Name: GSPT1
• UniProt Synonym Gene Names: ERF3A; Eukaryotic peptide chain release factor subunit 3a; eRF3a
• UniProt Entry Name: ERF3A_HUMAN

Uniprot Description

GSPT1 iso3: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Belongs to the GTP-binding elongation factor family. ERF3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Hydrolase; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: intracellular

Molecular Function: GTPase activity; protein binding; GTP binding; translation release factor activity

Biological Process: protein amino acid methylation; mRNA catabolic process, nonsense-mediated decay; translational termination; G1/S transition of mitotic cell cycle