EPN1 blocking peptide

EPN1 Antibody (Center) Blocking Peptide

• Synonyms: EPN1; EPN1 Antibody (Center) Blocking Peptide; Epsin-1; EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1; EPN1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 576

• Cellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit Note: Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EPN1 blocking peptide

Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.

NCBI and Uniprot Product Information

• NCBI GI #: 332278179
• NCBI GeneID: 29924
• UniProt Accession #: Q9Y6I3; Q86ST3; Q9HA18
• Molecular Weight: 57,504 Da
• NCBI Official Full Name: Epsin-1
• NCBI Official Synonym Full Names: epsin 1
• NCBI Official Symbol: EPN1
• NCBI Protein Information: epsin-1
• UniProt Protein Name: Epsin-1
• UniProt Gene Name: EPN1
• UniProt Entry Name: EPN1_HUMAN

NCBI Description

This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]

Uniprot Description

epsin 1: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis. Belongs to the epsin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway