EMILIN1 blocking peptide

EMILIN1 Antibody (N-term) Blocking Peptide

• Gene Names: EMILIN1; EMI; gp115; EMILIN
• Synonyms: EMILIN1; EMILIN1 Antibody (N-term) Blocking Peptide; EMILIN-1; Elastin microfibril interface-located protein 1; Elastin microfibril interfacer 1; EMI; EMILIN1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human EMILIN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1016

• Cellular Location: Secreted, extracellular space, extracellular matrix. Note: Found mainly at the interface between amorphous elastin and microfibrils
• Tissue Location: Distributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver, ovary, colon, stomach, lymph node and spleen; adult heart, bladder, prostate, adrenal gland, mammary gland, placenta and kidney showed low expression whereas a series of other adult tissues, including skeletal muscle and different regions of adult brain show no expression
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EMILIN1 blocking peptide

May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

NCBI and Uniprot Product Information

• NCBI GI #: 205371751
• NCBI GeneID: 11117
• UniProt Accession #: Q9Y6C2; Q53SY9; Q96G58; Q96IH6; Q9UG76; A5PL03; H0Y7A0
• Molecular Weight: 35,928 Da
• NCBI Official Full Name: EMILIN-1
• NCBI Official Synonym Full Names: elastin microfibril interfacer 1
• NCBI Official Symbol: EMILIN1
• NCBI Official Synonym Symbols: EMI; gp115; EMILIN
• NCBI Protein Information: EMILIN-1
• UniProt Protein Name: EMILIN-1
• Protein Family: EMILIN
• UniProt Gene Name: EMILIN1
• UniProt Synonym Gene Names: EMI; Elastin microfibril interfacer 1
• UniProt Entry Name: EMIL1_HUMAN

NCBI Description

This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009]

Uniprot Description

EMILIN1: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 2p23.3-p23.2

Cellular Component: extracellular matrix; extracellular region

Molecular Function: protein binding