Western Blot (WB)
(Western blot analysis of extracts from K562 cells, using CXCR3 antibody.)
Rabbit anti-Human CXCR3 Polyclonal Antibody | anti-CXCR3 antibody
CXCR3 Antibody
Gene Names
CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
Reactivity
Human
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
CXCR3; Polyclonal Antibody; CXCR3 Antibody; C-X-C chemokine receptor type 3; CD 183; CD182; CD183; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; Chemokine CXC Motif Receptor 3; CKR L2; CKR-L2; CKRL2; CMKAR3; CXC-R3; CXCR-3; CXCR3_HUMAN; G Protein Coupled Receptor 9; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 R; IP10 receptor; IP10-R; IP10R; Mig R; Mig receptor; Mig-R; MIGR; anti-CXCR3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
CXCR3 antibody detects endogenous levels of total CXCR3
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
415
Applicable Applications for anti-CXCR3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:500-1:1000
Immunogen
A synthesized peptide
Subcellular Location
Cell Membrane
Tissue Specificity
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Dog
Similarity
Pig (90%), Bovine (80%), Horse (90%), Sheep (80%), Dog (80%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from K562 cells, using CXCR3 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from K562 cells, using CXCR3 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from Hela, using CXCR3 Antibody.)
Western Blot (WB)
(Western blot analysis of extracts from Hela, using CXCR3 Antibody.)
Related Product Information for anti-CXCR3 antibody
Function: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
Subunit Structure: Homomer. Forms heteromers with ACKR4.
Post-translational Modifications: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated.
Similarity: Belongs to the G-protein coupled receptor 1 family.
Subunit Structure: Homomer. Forms heteromers with ACKR4.
Post-translational Modifications: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated.
Similarity: Belongs to the G-protein coupled receptor 1 family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 40 kD
Predicted: 41 kDa
Predicted: 41 kDa
NCBI Official Full Name
C-X-C chemokine receptor type 3 isoform 2
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 3
NCBI Official Symbol
CXCR3
NCBI Official Synonym Symbols
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
NCBI Protein Information
C-X-C chemokine receptor type 3
UniProt Protein Name
C-X-C chemokine receptor type 3
Protein Family
UniProt Gene Name
CXCR3
UniProt Synonym Gene Names
GPR9; CXC-R3; CXCR-3; IP-10 receptor
NCBI Description
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Uniprot Description
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
Research Articles on CXCR3
1. High CXCR3 expression is associated with invasion and metastasis in tongue squamous cell carcinoma.
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Product Notes
The CXCR3 cxcr3 (Catalog #AAA9606311) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CXCR3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CXCR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the CXCR3 cxcr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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