EFEMP2 blocking peptide

EFEMP2 Blocking Peptide

Cat. Num. AAA9624206

• Gene Names: EFEMP2; MBP1; UPH1; FBLN4; ARCL1B
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: EFEMP2; EFEMP2 Blocking Peptide; EFEMP 2; EGF containing fibulin like extracellular matrix protein 2; EGF-containing fibulin-like extracellular matrix protein 2; FBLN 4; FBLN4; FBLN4_HUMAN; FIBL 4; FIBL-4; FIBL4; Fibulin 4; Fibulin-4; MBP 1; MBP1; Mutant p53 binding protein 1; Protein UPH1; UPH 1; UPH1; UPH1 protein; EFEMP2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for EFEMP2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EFEMP2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 320118911
• NCBI GeneID: 30008
• NCBI Accession #: NP_058634.4
• NCBI GenBank Nucleotide #: NM_016938.4
• UniProt Accession #: O95967; O75967; A8K7R4; B3KM31; B3KQT1
• Molecular Weight: 49,405 Da
• NCBI Official Full Name: EGF-containing fibulin-like extracellular matrix protein 2
• NCBI Official Synonym Full Names: EGF containing fibulin-like extracellular matrix protein 2
• NCBI Official Symbol: EFEMP2
• NCBI Official Synonym Symbols: MBP1; UPH1; FBLN4; ARCL1B
• NCBI Protein Information: EGF-containing fibulin-like extracellular matrix protein 2; FIBL-4; fibulin 4; fibulin-4; mutant p53 binding protein 1
• UniProt Protein Name: EGF-containing fibulin-like extracellular matrix protein 2
• Protein Family: EGF-containing fibulin-like extracellular matrix protein
• UniProt Gene Name: EFEMP2
• UniProt Synonym Gene Names: FBLN4; FIBL-4
• UniProt Entry Name: FBLN4_HUMAN

NCBI Description

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

EFEMP2: Defects in EFEMP2 are the cause of cutis laxa, autosomal recessive, type 1B (ARCL1B). A connective tissue disorder characterized by characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. ARCL1B features include emphysema, lethal pulmonary artery occlusion, aortic aneurysm, cardiopulmonary insufficiency, birth fractures, arachnodactyly, and fragility of blood vessels. Belongs to the fibulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: plasma membrane; extracellular region; basement membrane; vesicle

Molecular Function: protein binding; transmembrane receptor activity; extracellular matrix structural constituent; calcium ion binding

Biological Process: extracellular matrix organization and biogenesis; signal transduction; blood coagulation

Disease: Cutis Laxa, Autosomal Recessive, Type Ib