Dyrk1B blocking peptide

Dyrk1B (T356) Peptide

Cat. Num. AAA3002927

• Applications: Blocking
• Purity: Synthetic peptide Dyrk1B (T356). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Dyrk1B; Dyrk1B (T356) Peptide; DYR 1B; DYR1A; DYR1B; DYRK 1B; Dyrk1b; Minibrain related kinase; Minibrain-related kinase; MIRK; Mirk protein kinase; Dyrk1B blocking peptide

• Specificity: This peptide can be used with studies using MBS3002926 Dyrk1B (T356) pAb.
• Purity/Purification: Synthetic peptide Dyrk1B (T356). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 629

• Applicable Applications for Dyrk1B blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Dyrk1B blocking peptide

Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is self regulated by tyrosine phosphorylation. Several related mammalian proteins compose the Dyrk family of dual specificity protein kinases, including Dyrk1A, Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B. The Dyrk family members are thought to be involved in the regulation of cellular growth and/or development. Dyrk1B localizes to the nucleus in muscle and testis. Specifically, Dyrk1B plays a critical role in muscle differentiation by regulating motility, transcription, cell cycle progression and cell survival. Dyrk1B is also found is several solid tumors, where it acts as a downstream effector of Rac1 or K-ras to mediate cell survival.

NCBI and Uniprot Product Information

• NCBI GI #: 4758222
• NCBI Accession #: NP_004705.1
• NCBI GenBank Nucleotide #: NP_004705.1
• UniProt Accession #: Q9Y463
• NCBI Official Full Name: dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B
• Protein Family: Dual specificity tyrosine-phosphorylation-regulated kinase
• UniProt Gene Name: DYRK1B
• UniProt Synonym Gene Names: MIRK
• UniProt Entry Name: DYR1B_HUMAN

Uniprot Description

DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.

Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor); CMGC group; DYRK family; Dyrk1 subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transcription coactivator activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; myoblast fusion

Disease: Abdominal Obesity-metabolic Syndrome 3