DSG2 blocking peptide

DSG2 Antibody (N-term T160) Blocking Peptide

• Gene Names: DSG2; HDGC; CDHF5
• Synonyms: DSG2; DSG2 Antibody (N-term T160) Blocking Peptide; Desmoglein-2; Cadherin family member 5; HDGC; CDHF5; DSG2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human DSG2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1118

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome
• Tissue Location: All of the tissues tested and carcinomas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DSG2 blocking peptide

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

NCBI and Uniprot Product Information

• NCBI GI #: 116534898
• NCBI GeneID: 1829
• NCBI Accession #: NP_001934
• NCBI GenBank Nucleotide #: NM_001943.4
• UniProt Accession #: Q14126; Q4KKU6
• Molecular Weight: 122,294 Da
• NCBI Official Full Name: desmoglein-2 preproprotein
• NCBI Official Synonym Full Names: desmoglein 2
• NCBI Official Symbol: DSG2
• NCBI Official Synonym Symbols: HDGC; CDHF5
• NCBI Protein Information: desmoglein-2
• UniProt Protein Name: Desmoglein-2
• Protein Family: Desmoglein
• UniProt Gene Name: DSG2
• UniProt Synonym Gene Names: CDHF5
• UniProt Entry Name: DSG2_HUMAN

NCBI Description

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]

Uniprot Description

DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Protein type: Cell adhesion; Calcium-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: cell surface; desmosome; intercellular junction; plasma membrane

Molecular Function: cell adhesion molecule binding

Biological Process: cell adhesion; homophilic cell adhesion

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 10; Cardiomyopathy, Dilated, 1bb