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DRAGON (RGMB) Blocking Peptide | RGMB blocking peptide

DRAGON (RGMB) Antibody (Center) Blocking Peptide

Gene Names
RGMB; DRAGON
Synonyms
DRAGON (RGMB); DRAGON (RGMB) Antibody (Center) Blocking Peptide; RGM domain family member B; DRG11-responsive axonal guidance and outgrowth of neurite; DRAGON; RGMB; RGMB blocking peptide
Ordering
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the RGMB region of human DRAGON (RGMB). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
437
Cellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for RGMB blocking peptide
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
47,547 Da
NCBI Official Full Name
RGM domain family member B
NCBI Official Synonym Full Names
repulsive guidance molecule family member b
NCBI Official Symbol
RGMB
NCBI Official Synonym Symbols
DRAGON
NCBI Protein Information
RGM domain family member B
UniProt Protein Name
RGM domain family member B
Protein Family
UniProt Gene Name
RGMB
UniProt Synonym Gene Names
DRAGON
UniProt Entry Name
RGMB_HUMAN

NCBI Description

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]

Uniprot Description

RGMB: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth. Belongs to the repulsive guidance molecule (RGM) family.

Protein type: Transcription regulation; Cell adhesion; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: anchored to plasma membrane; ER-Golgi intermediate compartment; plasma membrane

Molecular Function: coreceptor activity; identical protein binding

Biological Process: BMP signaling pathway; cell adhesion; positive regulation of transcription, DNA-dependent; signal transduction

Research Articles on RGMB

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Product Notes

The RGMB rgmb (Catalog #AAA9220576) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DRAGON (RGMB), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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