DPY19L2 blocking peptide
DPY19L2 Antibody (C-term) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011]
Uniprot Description
DPY19L2: Required during spermatogenesis for sperm head elongation and acrosome formation. Defects in DPY19L2 are the cause of spermatogenic failure type 9 (SPGF9). An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Deletions in DPY19L2 are probably the major cause of SPGF9. Belongs to the dpy-19 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q14.2
Cellular Component: nuclear inner membrane; nucleus
Molecular Function: mannosyltransferase activity
Biological Process: protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan; spermatid development
Disease: Spermatogenic Failure 9
Research Articles on DPY19L2
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Product Notes
The DPY19L2 dpy19l2 (Catalog #AAA9217378) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DPY19L2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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