DDX41 blocking peptide

DDX41 Peptide

Cat. Num. AAA154153

• Gene Names: DDX41; ABS
• Applications: Blocking (BL)
• Synonyms: DDX41; DDX41 Peptide; ABS; Probable ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DDX41 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 622

• Applicable Applications for DDX41 blocking peptide: Blocking (BL)
• Application Notes: DDX41 peptide is used for blocking the activity of DDX41 antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acid peptide near the amino terminus of human DDX41.
• Preparation and Storage: Store DDX41 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 21071032
• NCBI GeneID: 51428
• NCBI Accession #: NP_057306
• NCBI GenBank Nucleotide #: NM_016222.2
• UniProt Accession #: Q9UJV9; Q96BK6; Q96K05; Q9NT96; Q9NW04; B2RDC8
• Molecular Weight: 69,838 Da
• NCBI Official Full Name: probable ATP-dependent RNA helicase DDX41
• NCBI Official Synonym Full Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
• NCBI Official Symbol: DDX41
• NCBI Official Synonym Symbols: ABS
• NCBI Protein Information: probable ATP-dependent RNA helicase DDX41; 2900024F02Rik; DEAD box protein 41; putative RNA helicase; DEAD-box protein abstrakt; DEAD box protein abstrakt homolog
• UniProt Protein Name: Probable ATP-dependent RNA helicase DDX41
• Protein Family: Probable ATP-dependent RNA helicase
• UniProt Gene Name: DDX41
• UniProt Synonym Gene Names: ABS
• UniProt Entry Name: DDX41_HUMAN

NCBI Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

Uniprot Description

DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.

Protein type: Helicase; Spliceosome; RNA splicing; EC 3.6.4.13; RNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: membrane; endoplasmic reticulum; cytosol

Molecular Function: protein binding; DNA binding; zinc ion binding; helicase activity; ATP binding

Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; regulation of interferon type I production; apoptosis; multicellular organismal development; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; defense response to virus