DCP1A blocking peptide

DCP1A Antibody (N-term) Blocking Peptide

• Synonyms: DCP1A; DCP1A Antibody (N-term) Blocking Peptide; mRNA-decapping enzyme 1A; 3---; Smad4-interacting transcriptional co-activator; Transcription factor SMIF; SMIF; DCP1A blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 582

• Cellular Location: Cytoplasm, P-body. Nucleus. Note: Co- localizes with NANOS3 in the processing bodies (By similarity) Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
• Tissue Location: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DCP1A blocking peptide

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

NCBI and Uniprot Product Information

• NCBI GI #: 291327466
• NCBI GeneID: 55802
• NCBI Accession #: NP_060873.4
• NCBI GenBank Nucleotide #: NM_018403.6
• UniProt Accession #: Q9NPI6; B4DHN9; U3KQM8
• Molecular Weight: 59,361 Da
• NCBI Official Full Name: mRNA-decapping enzyme 1A isoform a
• UniProt Protein Name: mRNA-decapping enzyme 1A
• Protein Family: mRNA-decapping enzyme
• UniProt Gene Name: DCP1A
• UniProt Synonym Gene Names: SMIF
• UniProt Entry Name: DCP1A_HUMAN

Uniprot Description

DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling.

Protein type: EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane

Molecular Function: enzyme regulator activity; identical protein binding; mRNA binding; protein binding

Biological Process: deadenylation-dependent decapping; deadenylation-independent decapping; regulation of mRNA stability