DBP blocking peptide

DBP Blocking Peptide (C-term)

• Gene Names: DBP; DABP
• Synonyms: DBP; DBP Blocking Peptide (C-term); D site-binding protein; Albumin D box-binding protein; Albumin D-element-binding protein; Tax-responsive enhancer element-binding protein 302; TaxREB302; DBP blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 233-246 of HUMAN DBP
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 325

• Cellular Location: Nucleus.
• Tissue Location: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DBP blocking peptide

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 1706312
• NCBI GeneID: 1628
• UniProt Accession #: Q10586; A2I2P4
• Molecular Weight: 34,349 Da
• NCBI Official Full Name: D site-binding protein
• NCBI Official Synonym Full Names: D-box binding PAR bZIP transcription factor
• NCBI Official Symbol: DBP
• NCBI Official Synonym Symbols: DABP
• NCBI Protein Information: D site-binding protein
• UniProt Protein Name: D site-binding protein
• Protein Family: D site-binding protein
• UniProt Gene Name: DBP
• UniProt Synonym Gene Names: TaxREB302
• UniProt Entry Name: DBP_HUMAN

NCBI Description

The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

Uniprot Description

DBP: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. Belongs to the bZIP family. PAR subfamily.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.3

Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter