CYP4B1 blocking peptide

CYP4B1 Antibody (Center) Blocking Peptide

• Gene Names: CYP4B1; CYPIVB1; P-450HP
• Synonyms: CYP4B1; CYP4B1 Antibody (Center) Blocking Peptide; Cytochrome P450 4B1; CYPIVB1; Cytochrome P450-HP; CYP4B1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human CYP4B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 511

• Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
• Tissue Location: Detected in the liver and lung (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CYP4B1 blocking peptide

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

NCBI and Uniprot Product Information

• NCBI GI #: 48429213
• NCBI GeneID: 1580
• UniProt Accession #: P13584; Q1HBI2; Q8TD85; Q8WWF2; Q8WWU9; Q8WWV0
• Molecular Weight: 59,078 Da
• NCBI Official Full Name: Cytochrome P450 4B1
• NCBI Official Synonym Full Names: cytochrome P450 family 4 subfamily B member 1
• NCBI Official Symbol: CYP4B1
• NCBI Official Synonym Symbols: CYPIVB1; P-450HP
• NCBI Protein Information: cytochrome P450 4B1
• UniProt Protein Name: Cytochrome P450 4B1
• Protein Family: Cytochrome
• UniProt Gene Name: CYP4B1
• UniProt Entry Name: CP4B1_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

CYP4B1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.14.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: endoplasmic reticulum membrane

Molecular Function: oxygen binding