CRYAA blocking peptide

CRYAA Blocking Peptide(Center)

• Gene Names: CRYAA; CRYA1; HSPB4; CTRCT9
• Synonyms: CRYAA; CRYAA Blocking Peptide(Center); Alpha-crystallin A chain; Heat shock protein beta-4; HspB4; Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162); CRYA1; HSPB4; CRYAA blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 92-106 of HUMAN CRYAA
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 173

• Cellular Location: Cytoplasm. Nucleus. Note: Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles
• Tissue Location: Expressed in eye lens.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CRYAA blocking peptide

Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

NCBI and Uniprot Product Information

• NCBI GI #: 4503055
• NCBI GeneID: 1409
• NCBI Accession #: NP_000385.1
• NCBI GenBank Nucleotide #: NM_000394.3
• UniProt Accession #: P02489; Q53X53; AAB33370
• Molecular Weight: 19,909 Da
• NCBI Official Full Name: alpha-crystallin A chain
• NCBI Official Synonym Full Names: crystallin alpha A
• NCBI Official Symbol: CRYAA
• NCBI Official Synonym Symbols: CRYA1; HSPB4; CTRCT9
• NCBI Protein Information: alpha-crystallin A chain
• UniProt Protein Name: Alpha-crystallin A chain
• Protein Family: Alpha-crystallin
• UniProt Gene Name: CRYAA
• UniProt Synonym Gene Names: CRYA1; HSPB4; HspB4
• UniProt Entry Name: CRYAA_HUMAN

NCBI Description

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]

Uniprot Description

CRYA1: a major structural protein of the eye lens. A member of the small heat shock protein (sHSP, also known as the HSP20) family. Alpha-A is preferentially restricted to the lens.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; unfolded protein binding

Biological Process: negative regulation of apoptosis; negative regulation of intracellular transport; protein homooligomerization; protein refolding; visual perception

Disease: Cataract 9, Multiple Types