CPLX2 blocking peptide

CPLX2 Blocking Peptide (Center)

Gene Names

CPLX2; CPX2; Hfb1; 921-L; CPX-2

Synonyms

CPLX2; CPLX2 Blocking Peptide (Center); Complexin-2; Complexin II; CPX II; Synaphin-1; CPLX2 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 51-63 of HUMAN CPLX2

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

134

Cellular Location

Cytoplasm, cytosol. Note: Enriched at synaptic-releasing sites in mature neurons.

Tissue Location

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CPLX2 blocking peptide

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

51316998

NCBI GeneID

10814

UniProt Accession #

Q6PUV4; O09056; Q13329; Q28184; Q52M15; Q64386; B2RAG2

Molecular Weight

15,394 Da

NCBI Official Full Name

Complexin-2

NCBI Official Synonym Full Names

complexin 2

NCBI Official Symbol

CPLX2

NCBI Official Synonym Symbols

CPX2; Hfb1; 921-L; CPX-2

NCBI Protein Information

complexin-2

UniProt Protein Name

Complexin-2

Protein Family

Complexin

UniProt Gene Name

CPLX2

UniProt Synonym Gene Names

CPX II

UniProt Entry Name

CPLX2_HUMAN

NCBI Description

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CPLX2: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Belongs to the complexin/synaphin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 5q35.2

Biological Process: positive regulation of synaptic plasticity; regulation of exocytosis; vesicle docking during exocytosis

Research Articles on CPLX2

1. Then results indicated that CPLX2 may be involved in the etiology of schizophrenia and one of its potential biological mechanisms by studying the effects of CPLX2 risk variants on working memory load-dependent neural activity in a frontoparietal network.

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Product Notes

The CPLX2 cplx2 (Catalog #AAA9229368) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CPLX2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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CPLX2 blocking peptide