COPS5 blocking peptide

COPS5 Blocking Peptide (Center)

• Gene Names: COPS5; CSN5; JAB1; SGN5; MOV-34
• Synonyms: COPS5; COPS5 Blocking Peptide (Center); COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; 34--; Jun activation domain-binding protein 1; CSN5; JAB1; COPS5 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 187-202 of HUMAN COPS5
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 334

• Cellular Location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note: Nuclear localization is diminished in the presence of IFIT3
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for COPS5 blocking peptide

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

NCBI and Uniprot Product Information

• NCBI GI #: 55976562
• NCBI GeneID: 10987
• UniProt Accession #: Q92905; O15386; Q6AW95; Q86WQ4; Q9BQ17
• Molecular Weight: 37,579 Da
• NCBI Official Full Name: COP9 signalosome complex subunit 5
• NCBI Official Synonym Full Names: COP9 signalosome subunit 5
• NCBI Official Symbol: COPS5
• NCBI Official Synonym Symbols: CSN5; JAB1; SGN5; MOV-34
• NCBI Protein Information: COP9 signalosome complex subunit 5
• UniProt Protein Name: COP9 signalosome complex subunit 5
• UniProt Gene Name: COPS5
• UniProt Synonym Gene Names: CSN5; JAB1; SGN5; Signalosome subunit 5
• UniProt Entry Name: CSN5_HUMAN

NCBI Description

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Uniprot Description

COPS5: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, p27Kip1, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Belongs to the peptidase M67A family. CSN5 subfamily.

Protein type: Adaptor/scaffold; Translation; Protease; Transcription, coactivator/corepressor; Nuclear receptor co-regulator; EC 3.4.-.-

Chromosomal Location of Human Ortholog: 8q13.1

Cellular Component: cytoplasm; eukaryotic translation initiation factor 3 complex; nucleoplasm; nucleus; signalosome; synaptic vesicle

Molecular Function: metallopeptidase activity; protein binding; transcription coactivator activity; translation initiation factor activity; ubiquitin-specific protease activity

Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; positive regulation of transcription from RNA polymerase II promoter; protein deneddylation; protein deubiquitination; regulation of JNK cascade; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; translation