CNTN2 blocking peptide

CNTN2 Antibody (Center) Blocking peptide

• Gene Names: CNTN2; AXT; TAX; TAX1; FAME5; TAG-1
• Synonyms: CNTN2; CNTN2 Antibody (Center) Blocking peptide; Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; Transient axonal glycoprotein 1; TAX-1; AXT; TAG1; TAX1; CNTN2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1040

• Cellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Note: Attached to the neuronal membrane by a GPI-anchor and is also released from neurons
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CNTN2 blocking peptide

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.

NCBI and Uniprot Product Information

• NCBI GI #: 4827022
• NCBI GeneID: 6900
• NCBI Accession #: NP_005067.1
• NCBI GenBank Nucleotide #: NM_005076.3
• UniProt Accession #: Q02246; P78432; Q5T054
• Molecular Weight: 113,393 Da
• NCBI Official Full Name: contactin-2
• NCBI Official Synonym Full Names: contactin 2
• NCBI Official Symbol: CNTN2
• NCBI Official Synonym Symbols: AXT; TAX; TAX1; FAME5; TAG-1
• NCBI Protein Information: contactin-2
• UniProt Protein Name: Contactin-2
• Protein Family: Contactin
• UniProt Gene Name: CNTN2
• UniProt Synonym Gene Names: AXT; TAG1; TAX1; TAX-1
• UniProt Entry Name: CNTN2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq, Jul 2008]

Uniprot Description

CNTN2: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. Belongs to the immunoglobulin superfamily. Contactin family.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: integral to plasma membrane; myelin sheath; plasma membrane; synapse

Molecular Function: identical protein binding

Biological Process: clustering of voltage-gated potassium channels

Disease: Epilepsy, Familial Adult Myoclonic, 5