CNOT4 blocking peptide

CNOT4 Antibody (N-term) Blocking Peptide

• Gene Names: CNOT4; NOT4; NOT4H; CLONE243
• Synonyms: CNOT4; CNOT4 Antibody (N-term) Blocking Peptide; CCR4-NOT transcription complex subunit 4; 632-; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp; NOT4; CNOT4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CNOT4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 575

• Cellular Location: Cytoplasm. Nucleus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CNOT4 blocking peptide

Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 115502372
• NCBI GeneID: 4850
• UniProt Accession #: O95628; O95339; O95627; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6; B7Z6I4; E7ET38; F8VQP3
• Molecular Weight: 78,257 Da
• NCBI Official Full Name: CCR4-NOT transcription complex subunit 4
• NCBI Official Synonym Full Names: CCR4-NOT transcription complex subunit 4
• NCBI Official Symbol: CNOT4
• NCBI Official Synonym Symbols: NOT4; NOT4H; CLONE243
• NCBI Protein Information: CCR4-NOT transcription complex subunit 4
• UniProt Protein Name: CCR4-NOT transcription complex subunit 4
• Protein Family: CCR4-NOT transcription complex
• UniProt Gene Name: CNOT4
• UniProt Synonym Gene Names: NOT4
• UniProt Entry Name: CNOT4_HUMAN

NCBI Description

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Uniprot Description

CNOT4: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: CCR4-NOT complex; cytosol

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; poly(A) tail shortening; protein autoubiquitination