CLDN15 blocking peptide

CLDN15 Antibody (Center) Blocking Peptide

• Synonyms: CLDN15; CLDN15 Antibody (Center) Blocking Peptide; Claudin-15; CLDN15 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 228

• Cellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note: Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy
• Tissue Location: Detected in colon (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CLDN15 blocking peptide

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.

NCBI and Uniprot Product Information

• NCBI GI #: 6685306
• NCBI GeneID: 24146
• UniProt Accession #: P56746; B3KPB5
• Molecular Weight: 24,356 Da
• NCBI Official Full Name: Claudin-15
• NCBI Official Synonym Full Names: claudin 15
• NCBI Official Symbol: CLDN15
• NCBI Protein Information: claudin-15
• UniProt Protein Name: Claudin-15
• Protein Family: Claudin
• UniProt Gene Name: CLDN15
• UniProt Entry Name: CLD15_HUMAN

NCBI Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

Claudin-15: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.

Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.22

Cellular Component: tight junction

Molecular Function: identical protein binding

Biological Process: calcium-independent cell-cell adhesion