CHSY3 blocking peptide

CHSY3 Blocking Peptide (Center)

Gene Names

CHSY3; CSS3; CHSY2

Synonyms

CHSY3; CHSY3 Blocking Peptide (Center); Chondroitin sulfate synthase 3; Carbohydrate synthase 2; Chondroitin glucuronyltransferase 3; Chondroitin synthase 2; ChSy-2; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3; N-acetylgalactosaminyltransferase 3; CHSY2; CSS3; CHSY3 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 546-560 of HUMAN CHSY3

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

882

Cellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein

Tissue Location

Detected at low levels in brain, cerebral cortex, uterus and small intestine.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHSY3 blocking peptide

Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.

NCBI and Uniprot Product Information

NCBI GI #

74271903

NCBI GeneID

337876

NCBI Accession #

NP_787052.3

NCBI GenBank Nucleotide #

NM_175856.4

UniProt Accession #

Q70JA7; Q76L22; Q86Y52; B2RP97

Molecular Weight

100,284 Da

NCBI Official Full Name

chondroitin sulfate synthase 3

NCBI Official Synonym Full Names

chondroitin sulfate synthase 3

NCBI Official Symbol

CHSY3

NCBI Official Synonym Symbols

CSS3; CHSY2

NCBI Protein Information

chondroitin sulfate synthase 3

UniProt Protein Name

Chondroitin sulfate synthase 3

Protein Family

Chondroitin sulfate synthase

UniProt Gene Name

CHSY3

UniProt Synonym Gene Names

CHSY2; CSS3; ChSy-2

UniProt Entry Name

CHSS3_HUMAN

NCBI Description

CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]

Uniprot Description

CSS3: Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. Belongs to the chondroitin N- acetylgalactosaminyltransferase family.

Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.175; EC 2.4.1.226

Chromosomal Location of Human Ortholog: 5q23.3

Cellular Component: Golgi membrane

Molecular Function: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Biological Process: chondroitin sulfate biosynthetic process

Research Articles on CHSY3

1. The present study focused on the expression of chondroitin-synthesizing enzymes in colorectal cancer.

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Product Notes

The CHSY3 chsy3 (Catalog #AAA9228775) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CHSY3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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CHSY3 blocking peptide