CHRNB4 blocking peptide

CHRNB4 Blocking Peptide (C-term)

Synonyms

CHRNB4; CHRNB4 Blocking Peptide (C-term); Neuronal acetylcholine receptor subunit beta-4; CHRNB4 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 437-450 of HUMAN CHRNB4

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

498

Cellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHRNB4 blocking peptide

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

NCBI and Uniprot Product Information

NCBI GI #

4502837

NCBI GeneID

1143

NCBI Accession #

NP_000741.1

NCBI GenBank Nucleotide #

NM_000750.3

UniProt Accession #

P30926; Q16607; Q4VBA5; Q8WXC8; Q9BQR4; A4FTX5; E9PHE8

Molecular Weight

25,862 Da

NCBI Official Full Name

neuronal acetylcholine receptor subunit beta-4 isoform 1

NCBI Official Synonym Full Names

cholinergic receptor nicotinic beta 4 subunit

NCBI Official Symbol

CHRNB4

NCBI Protein Information

neuronal acetylcholine receptor subunit beta-4

UniProt Protein Name

Neuronal acetylcholine receptor subunit beta-4

Protein Family

Neuronal acetylcholine receptor

UniProt Gene Name

CHRNB4

UniProt Entry Name

ACHB4_HUMAN

Uniprot Description

nAChRB4: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 4/CHRNB4 sub-subfamily.

Protein type: Membrane protein, integral; Receptor, misc.; Channel, ligand-gated; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: integral to plasma membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity

Biological Process: ion transport; response to nicotine; signal transduction; synaptic transmission involved in micturition; synaptic transmission, cholinergic

Research Articles on CHRNB4

1. Data suggest that CHRNA5-A3-B4 gene variants do not exhibit a robust association with smoking cessation and are unlikely to be useful for clinically optimizing smoking cessation pharmacotherapy for Caucasian smokers.

Similar Products

Product Notes

The CHRNB4 chrnb4 (Catalog #AAA9228803) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CHRNB4, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...

CHRNB4 blocking peptide